There are many types of approaches you can use in pairs trading, but the Distance Approach is one of the most widely used because of its simplicity. The basic concept is as follows: Using Euclidean squared distance on the normalized price time series, n closest pairs of assets are chosen as pairs.
Then, with selected pairs, if the difference between the price of elements in a pair diverged by more than a threshold(ex. 2 standard deviations), the positions are opened. We have a long position for a stock with a lower price and a short position for a higher price in the portfolio.